Where at in Pennsylvania?
In Pittsburgh we have a few different comic and toy conventions, as well as a big anime convention each year- Tekko. I go to Tekko and cosplay every year and it's really fun. And like I said, there are typically several comic conventions to choose from. One of them, Steel City Con, even happens multiple tines a year, and they have decent guest appearances and lots of vintage (and newer) toys for sale! If you're into the furry scene, Pittsburgh hosts the largest furry convention in North America each year. I've never gone, but I have friends who do and they love it!
I don't know much about the con scene near Philly, but since it's the only other "big" city in PA, I'm sure they have a lot to offer.
Oh, and of course any cons in the surrounding states won't be too far. My friends and I are driving to NJ next month for AnimeNEXT. I prefer small-ish cons, although NYCC is on my list to eventually get to since NYC isn't too far a drive, either.