I had a pretty serious falling out with my best friend. Haven't talked to them in over a year and a half. Unfortunately that bridge is burnt, and if you ask me who my best friend is today, I'd still list them. They're the type of person you seldom meet, and I miss them every freakin' day.
In other, less depressing news, I've been friends with my podcast cohort for about seven years now. I didn't get into ponies till I had known him for about six years. Our conversational topics have definitely changed since then!