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Don´t use a hair straightener unless you know the temperature is low enough and the hair is soaked enough or it will melt. It kinda speaks for itself, but that´s my biggest fail so far (which my poor Baby Brightbow can testify!).
Don't put Twinkle Eye ponies in an Oxyclean bath.
Why then do these spots show up chronically in certain colors only? If it was purely based on environmental factors, the distribution should be ubiquitous. The evidence doesn't fit the facts. There's some old posts about bacteria eating plasticizers, yes, but in the same breath they recommend an acne cream (Remove-Zit) as the perfect treatment, something we know is a terrible idea now.
Ponies have developed age spots in conditions that preclude bacterial growth - under 50% humidity. For all we know its a commonality rather than causation. For that matter there's likely more than one agent causing discolourations, which we tend to lump together under one umbrella term.