Oh gosh, absolutely. I'd be lost without my comfort objects!
(photos aren't working for me at the moment, nor is much else, so you'll just get a wordy rundown)
1) One of my oldest and most faithful plush friends is a Pound Purrie named Pinky Bows (she... came with a pink bow), and she's got a spot in my room where she can watch over the bed and get patted in passing. I figure that by Velveteen Rabbit standards, I have made her real. Her whiskers have worn away, the paint on her eyes has chipped, no part of her is its original color... she's been loved very nearly to pieces.
2) Laurent is a realistic plush octopus that a friend sent me (she actually gave me a pair, one realistic and one not, but Laurent just happens to have a really good shape for hugging). He's not just soft and easy to cuddle into my chest, but he reminds me that even when I'm physically alone, someone on the other side of the country cares about me a lot and knows what I like.
3) The kitten bouquet. A different friend had a bouquet of nine stuffed kittens sent to me, and it came at a time when I was stressed out and just made my day, and because the little kittens themselves are so small, it's easy to just hold one in one hand while I type with the other, if I'm working at my computer at home and need something soft to hold (and my living, breathing cat doesn't feel like complying). All nine have names.
And the newest... Pink Bunny the Second!
When I was really small, I had a plush rabbit, bright pink and white. It was my best friend, basically. It was a little older than Pinky Bows, iirc, and one day at the public library, another kid picked her up and walked away with her and my parents took me home without her, and I know it sounds like a sad sign of arrested development, but it messed me up and I mourned her for years.
Cut to me very recently as an adult. I deal with depression and anxiety (which is why comfort objects like my plush collection, my dolls, and my fuzzy throw blankets are so important, because I need all the comfort I can get), and I was in a really bad low, and the Easter stuff had just started to come in at Target.
They had this stuffed dutch bunny that came in a couple of pastels, and my family came home from a shopping trip with the pink one for me as a surprise. I must have spent two straight days just hugging that bun, and despite my tossing and turning and the lack of real space in my bed, I slept with her there for about a week before finding her a stable spot.