Well, even within the cartoon itself they weren’t very consistent. At one point Teddy blackmails Bon Bon to go to the dance with him. (What a winner.) As for the comics, I only have on issue focusing on Tales so I don’t know how different they are. They are still basically anthro ponies in a non-magical world.
The pre-tales G1 comics are much different than “MLP & Friends”. Basically they are a whole separate continuity in and of themselves.