I had to figure this one out the hard way, and about 2 days ago no less!
I had to paint over triple thick and I haven't had any problems so far. The areas were small, I imagine larger areas would have to deal a little bit with a texture issue depending on how thick the triple thick was applied.
(I was sealing a cute little symbol with triple thick and it.....destroyed it!!! The symbol had been cured for a few days, Createx artist paints no less. I applied the triple thick and the painting just smeared everywhere! I have never had that happen. I had to let everything cure again and then repainted the symbol over the triple thick mess. Oddly, same paints, same pony, the eyes took the triple thick just fine. Go figure.)