So here's an update.
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I've decided to go with BlackCurtains'(s?) idea that the cancer is a bacteria that is breaking down the plastic.
I opened up both QB and an Applejack with more pindot than orange and took off their markings but not any eye/blush/freckles with some acetone. Then I separated out the bodies individually into bags but kept both heads together (thrifty me).
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loginThey sat in double baggies for nearly a week in a Bar Keeper's friend/Palmolive Free&Clear/water paste mixture. Every couple or few hours I would squish the bags to provide some man powered cleaning and let out excess air.
The only real casualty seems to be to the blushes. The eyes and freckles remained perfectly fine. QB is significantly lighter both in body and in the cancer marks. His age marks on his head faded just as significantly as the cancer even though the head was in the solution for markedly less time... because I waffled about doing his whole body. The center dot is now a faint orangey color I have to look close to find.
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loginThe Applejack came out brighter and a little cleaner (and without her blush...) but the pindot remained relatively unaffected. The exposed hair feels cleaner and almost conditioned now. So, plus.
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loginThis seems to be something I'd recommend mostly as an alternative to sunfading.
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I have a few lighter colored ponies I'm going to try this on to see how they do. I proclaim QB as done with my current line of investigations and ready for his departure into custom-pony land.